Table 1.
VT, K1, k2, k3, and k4 values derived by compartmental modeling for baseline and inhibitor scans
| Brain region | Control |
Post-SE |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| VT (ml · cm−3) | K1 (ml · cm−3 min−1) | k2 (min−1) | k3 (min−1) | k4 (min−1) | VT (ml · cm−3) | K1 (ml · cm−3 min−1) | k2 (min−1) | k3 (min−1) | k4 (min−1) | |
| Baseline scan | ||||||||||
| Cerebellum | 2.23 ± 0.40 (5.2) | 0.19 ± 0.04 (12.8) | 0.28 ± 0.06 (30.1) | 0.11 ± 0.05 (35.9) | 0.05 ± 0.02 (19.3) | 1.49 ± 0.09 (6.2)* | 0.14 ± 0.02 (13.5)* | 0.29 ± 0.06 (30.1) | 0.10 ± 0.04 (37.2) | 0.05 ± 0.02 (19.2) |
| Frontal motor cortex | 2.38 ± 0.67 (6.0) | 0.17 ± 0.07 (12.3) | 0.22 ± 0.09 (33.1) | 0.12 ± 0.07 (41.1) | 0.05 ± 0.02 (24.3) | 2.04 ± 0.37 (6.1) | 0.16 ± 0.03 (15.6) | 0.29 ± 0.15 (38.8) | 0.14 ± 0.09 (44.6) | 0.06 ± 0.02 (23.4) |
| Corpus striatum | 1.50 ± 0.31 (7.8) | 0.11 ± 0.03 (15.5) | 0.26 ± 0.07 (39.5) | 0.11 ± 0.05 (45.2) | 0.04 ± 0.02 (25.0) | 1.42 ± 0.35 (6.1) | 0.11 ± 0.02 (15.8) | 0.29 ± 0.09 (38.8) | 0.12 ± 0.07 (60.2) | 0.05 ± 0.02 (22.5) |
| Hippocampus | 1.28 ± 0.15 (6.8) | 0.11 ± 0.03 (17.7) | 0.30 ± 0.07 (39.1) | 0.12 ± 0.04 (49.6) | 0.05 ± 0.01 (23.5) | 1.25 ± 0.12 (4.9) | 0.13 ± 0.02 (23.4) | 0.34 ± 0.04 (41.1) | 0.12 ± 0.02 (42.4) | 0.05 ± 0.01 (18.1) |
| Thalamus | 1.35 ± 0.25 (7.9) | 0.11 ± 0.01 (18.7) | 0.26 ± 0.08 (36.8) | 0.10 ± 0.04 (55.2) | 0.05 ± 0.01 (35.2) | 1.08 ± 0.03 (4.9)* | 0.14 ± 0.03 (23.2)* | 0.37 ± 0.08 (43.7) | 0.12 ± 0.06 (49.3) | 0.03 ± 0.01 (23.6)* |
| Inhibitor scan | ||||||||||
| Cerebellum | 6.14 ± 0.54 (3.0) | 0.73 ± 0.14 (11.7) | 0.32 ± 0.13 (46.3) | 0.30 ± 0.08 (76.2) | 0.20 ± 0.05 (26.9) | 3.59 ± 0.49 (2.6)* | 0.43 ± 0.05 (16.4)* | 0.54 ± 0.20 (49.3)* | 0.30 ± 0.13 (49.3) | 0.10 ± 0.04 (23.6)* |
| Frontal motor cortex | 7.33 ± 0.82 (1.7) | 0.63 ± 0.08 (9.5) | 0.24 ± 0.05 (49.6) | 0.32 ± 0.09 (68.7) | 0.19 ± 0.06 (23.8) | 8.69 ± 0.70 (2.4)* | 0.61 ± 0.15 (13.5) | 0.31 ± 0.09 (65.7) | 0.39 ± 0.10 (63.4) | 0.12 ± 0.05 (21.2) |
| Corpus striatum | 8.89 ± 1.08 (2.7) | 0.79 ± 0.13 (10.5) | 0.28 ± 0.08 (46.6) | 0.47 ± 0.22 (53.4) | 0.22 ± 0.06 (23.1) | 9.60 ± 0.77 (2.1) | 0.76 ± 0.23 (12.1) | 0.38 ± 0.15 (53.8) | 0.42 ± 0.08 (51.8) | 0.12 ± 0.06 (22.0)* |
| Hippocampus | 8.17 ± 0.91 (2.2) | 0.75 ± 0.11 (11.1) | 0.32 ± 0.08 (57.9) | 0.43 ± 0.09 (69.4) | 0.18 ± 0.05 (23.8) | 8.55 ± 1.03 (2.3) | 0.74 ± 0.19 (16.4) | 0.46 ± 0.08 (50.2)* | 0.42 ± 0.09 (48.3) | 0.10 ± 0.04 (17.7)* |
| Thalamus | 9.64 ± 1.06 (2.0) | 0.93 ± 0.12 (9.0) | 0.33 ± 0.18 (48.8) | 0.47 ± 0.11 (64.4) | 0.23 ± 0.06 (23.6) | 7.81 ± 0.95 (2.4)* | 0.85 ± 0.21 (14.7) | 0.54 ± 0.06 (41.4)* | 0.39 ± 0.07 (37.0) | 0.10 ± 0.03 (13.6)* |
Values are given as mean ± SD. Significant differences between control and post-SE rats are indicated (*p ≤ 0.05). The value in parentheses represents the precision of parameter estimates (expressed as their coefficient of variation in percentage), averaged over all rats per group.