Table 4.
Changes in haematological values between infected versus artemether-lumefantrine drug-treated mice.
| Parameter | Experimental group (N = 6) | |||
|---|---|---|---|---|
| (at the end of the experiment) | t value | P value | ||
| Infected (INF) | Drug-treated artemether-lumefantrine (DT AL) | |||
| HGB (g/dL) | 7.93 ± 0.175 | 11.08 ± 0.770 | 9.77 | <0.001** |
| RBC (106/mm3) | 5.90 ± 0.201 | 7.78 ± 0.317 | 12.23 | <0.0001*** |
| PCV (%) | 28.92 ± 1.46 | 33.67 ± 2.94 | 3.54 | <0.05* |
| MCV (fL) | 81.07 ± 2.19 | 87.0 ± 1.79 | 5.14 | <0.001** |
| MCH (pg) | 27.67 ± 1.17 | 28.7 ± 1.16 | 1.54 | >0.05NS |
| MCHC (g/dL) | 33.17 ± 1.08 | 33.33 ± 1.34 | 1.54 | >0.05NS |
| PLT (103/mm3) | 516.7 ± 23.4 | 680 ± 11.4 | 15.38 | <0.0001*** |
| WBC (cells/mm3) | 6957 ± 102 | 8033 ± 378 | 6.74 | <0.001** |
| Neutrophils (%) | 28.3 ± 0.724 | 41.00 ± 1.41 | 19.58 | <0.0001*** |
| Lymphocytes (%) | 69.70 ± 2.00 | 58.33 ± 4.55 | 5.61 | <0.001** |
| Monocytes (%) | 1.0 ± 0.117 | 1.0 ± 0.297 | 0.00 | >0.05NS |
| Eosinophils (%) | 1.0 ± 0.669 | 2.0 ± 0.566 | 0.00 | <0.05* |
The values are given as mean ± SD are statistically significant at t > 2.306, P < 0.05*, P < 0.001**, and P < 0.0001***; not significant at P > 0.05; HGB: hemoglobin; RBC: red blood cells; PCV: packed cell volume; MCV: mean cell volume; MCH: mean cell hemoglobin; MCHC: mean cell hemoglobin concentration; PLT: platelets; WBC: white blood cells.