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. Author manuscript; available in PMC: 2013 Jun 26.
Published in final edited form as: J Thorac Oncol. 2012 Oct;7(10):1583–1593. doi: 10.1097/JTO.0b013e31826146ee

FIGURE 4.

FIGURE 4

The effect of patient noncompliance on the risk of resistance. A, Effect of missing doses on the probability of resistance as a function of time, for nonsmoking patients with no preexisting resistance. B, Dynamics of the number of sensitive cells for compliant and noncompliant dosing schedules (missing 1, 2, and 3 days starting with day 7). C, Drug concentration in plasma over time (in μM) for compliant schedule of 150 mg/d, a noncompliant schedule missing days 7/8 and taking twice the dose on days 8/9, and a noncompliant schedule missing days 7/8 with no make-up doses. D, Probability of resistance for each of these schedules. E, Drug concentration in plasma over time (in μM) for schedule taking 150 mg and 100 mg on alternate days, and the standard schedule of 150 mg/d. F, Expected size of the resistant clone as a function of time for the schedules shown in (E), assuming 100 preexisting resistant cells. For all panels, the mutation rate is μ =10−8 per cell division and the initial population size is M = 106 cells with no preexisting resistance.