Table 7.1.

Summary of in vitro studies on the effects of GC on adiponectin expression

References	Type of GC	Concentration and duration of exposure	Culture system	Effects on adiponectin mRNA/protein expression
Downregulation
Fasshauer et al. (2003)	Dexamethasone	100 nM for 16 h	3T3-L1 preadipocytes	Decrease in protein expression/secretion
Fasshauer et al. (2002)	Dexamethasone	100 nM for 16 h	3T3-L1 preadipocytes	Decrease in mRNA expression
Halleux et al. (2001)	Dexamethasone	50 nM for 20 h	Isolated adipocytes from human visceral adipose tissue	Decrease in mRNA expression
Degawa-Yamauchi et al. (2005)	Dexamethasone	100 nM for 48 h	Human subcutaneous adipocytes	Decrease in protein secretion
No regulation
Hozumi et al. (2010)	Dexamethasone	1 μM for 24 h	Human bone marrow adipocytes	No change in protein secretion
Sakamoto et al. (2011)	Dexamethasone	1 μM for 24 h	Human bone marrow adipocytes	No change in mRNA expression
Ryan et al. (2010)	Dexamethasone	2 and 20 nM for 2 and 24 h	Differentiated canine adipocytes	No change in mRNA expression
de Oliveira, Iwanaga-Carvalho, et al. (2011b)	Dexamethasone	1 μM for 24 h	3T3-L1 adipocytes	No change in mRNA expression