Table 7.2.

Summary of animal studies on the effects of GC on adiponectin expression

References	Type of GC	Dosing regimen	Model system	Effects on adiponectin mRNA/protein expression
Negative regulation
Shi et al. (2010)	Hydrocortisone	Peritoneal injection of 5 or 15 mg/kg/day for 20 days	SPF Sprague–Dawley rats	Decrease in mRNA expression and plasma protein concentrations
Morton et al. (2004)	Predicted decrease in intracellular GC in adipose tissue	NA	11βHSD1 knockout in adipose tissue and matched wild type controls	11βHSD1 KO increases adiponectin mRNA expression
Kershaw et al. (2005)	Predicted decrease in intracellular GC in adipose tissue	NA	11βHSD2 overexpression in adipose tissue with high-fat feeding	11βHSD2 overexpression in adipose tissue of high-fat fed animals results in increase in adiponectin mRNA expression
Positive regulation
Combs et al. (2003)	Prednisolone	2.1 mg/kg/day for 28 days	Swiss Webster mice	Increase in plasma protein concentrations
Raff and Bruder (2006)	Dexamethasone	Subcutaneous tapering dosing regimen (from 0.5 mg/kg to 0.05 mg/kg)	Neonatal Sprague–Dawley rats	Increase in plasma protein concentrations
Effects of adrenalectomy
Makimura, Mizuno, Bergen, and Mobbs (2002)	Removal of endogenous GC	NA	ob/ob and matched wild type mice	Increase in serum protein and mRNA expression in ob/ob mice but decrease in serum protein and no change in mRNA expression in wild type
de Oliveira et al. (2011a)	Removal of endogenous GC and supplementation with dexamethasone	Subcutaneous dosing of 2 mg/kg, twice daily for 3 days	Male Wistar rats	Decrease in serum adiponectin and mRNA expression in epididymal fat with dex dosing
de Oliveira, Iwanaga-Carvalho, et al. (2011b)	Removal of endogenous GC and supplementation with dexamethasone	Subcutaneous dosing of 2 mg/kg, twice daily for 3 days	Male Wistar rats	Decrease in serum adiponectin with dex dosing and decrease in mRNA expression in epididymal fat with adrenalectomy