Table 3.
Results of Pancreatic MALDI-TOF Analysis: Details for contiguous spectral regions flagged as differentially expressed between cancer and normal spectra using WFMM analysis, including endpoints of contiguous region (x1, x2), number of detected peaks in region (Peaks) and how many flagged as significant by Cromwell analysis (sigPeaks), mean probability of 1.25-fold expression (meanP), maximum probability of 1.25-fold expression (maxP), and maximum absolute fold-change (maxFC) in region. Included in italics are the two peaks flagged by the Cromwell analysis but falling short of significance threshold for WFMM. Bold rows are those that would have been missed had only a peak-based Cromwell analysis been done, and those in red did not even have a peak detected in the flagged region.
| x1 | x2 | Peaks | sigPeaks | meanP | maxP | maxFC |
|---|---|---|---|---|---|---|
| 4711.7 | 1 | 1 | 0.42 | 0.67 | ||
| 5819.1 | 5824.2 | 1 | 0 | 0.63 | 0.65 | 1.53 |
| 5836.3 | 5846.7 | 1 | 0 | 0.75 | 0.85 | 1.59 |
| 8555.6 | 8566.0 | 1 | 0 | 0.92 | >0.99 | 0.56 |
| 8576.5 | 8578.6 | 1 | 0 | 0.62 | 0.63 | 0.65 |
| 8618.3 | 8628.8 | 1 | 0 | 0.96 | >0.99 | 0.58 |
| 8670.8 | 8683.5 | 0 | 0 | 0.88 | 0.97 | 0.59 |
| 8729.8 | 8786.9 | 2 | 1 | 0.88 | >0.99 | 0.45 |
| 9126.8 | 9141.9 | 1 | 1 | 0.82 | 0.92 | 0.61 |
| 9337.3 | 9354.8 | 1 | 1 | 0.80 | 0.92 | 0.61 |
| 9389.8 | 9453.4 | 1 | 1 | 0.84 | 0.97 | 0.59 |
| 9621.0 | 9645.4 | 2 | 2 | 0.75 | 0.83 | 0.62 |
| 10644 | 10646 | 1 | 0 | 0.62 | 0.62 | 0.65 |
| 11314 | 12037 | 17 | 7 | 0.94 | >0.99 | 2.77 |
| 12071 | 12099 | 0 | 0 | 0.61 | 0.62 | 1.53 |
| 13528 | 13573 | 1 | 0 | 0.83 | 0.97 | 0.55 |
| 13750 | 13763 | 1 | 0 | 0.82 | 0.92 | .59 |
| 13877 | 1 | 1 | 0.25 | 0.70 | ||
| 17103 | 17171 | 2 | 0 | 0.95 | >0.99 | 0.53 |
| 17230 | 17311 | 1 | 1 | 0.90 | >0.99 | 0.41 |