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Gene variants predict weight gain across 8 weeks of risperidone treatment. (a) A greater risk for weight gain is conferred by T-allele dosage at cannabinoid receptor (CNR1) rs806378 (P=1.0 × 10−6). (b) The G-allele of leptin (LEP) rs7799039 acts dominantly to increase risk for antipsychotic-induced weight gain (P=1.4 × 10−4), whereas AA homozygotes are relatively protected.
