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. 2013 Jun 25;3(6):e274. doi: 10.1038/tp.2013.26

Table 2. Association of genetic variants in energy balance pathways with AIWG.

Gene SNP ID (rs#) Gene region Our MAF HapMap MAF P-value Prior association
FTO rs1421085 Intron 1 0.33 0.45 0.13 12
  rs6499640 Intron 1 0.41 0.35 0.88 81
  rs1121980 Intron 1 0.41 0.48 0.78 12, 82
  rs17817449a Intron 1 0.39 0.45   83
  rs8050136a Intron 1 0.38 0.45   12
  rs9939609a Intron 1 0.38 0.45   11, 73
MC4R rs8087522 Promoter 0.36 0.36 0.06 41, 84
  rs11872992 Promoter 0.12 0.13 0.03 41, 84
  rs8093815 3′ Downstream 0.32 0.33 0.07  
  rs489693 3′ Downstream 0.39 0.34 0.03 85
LEP rs7799039 promoter 0.43 0.49 1.4 × 10−4 72, 86, 87
  rs10244329 Intron 1 0.49 0.47 9.6 × 10−3 88
  rs12706832 Intron 1 0.49 0.57 0.09  
  rs2071045 Intron 2 0.24 0.21 0.19 89
CNR1 rs806378 Variableb 0.24 0.26 1.0 × 10−6 44
  rs806377 Promoter 0.46 0.49 0.17  
  rs1049353 Synonymous 0.23 0.23 9.6 × 10−5  
  rs806368 3′UTR 0.18 0.25 0.26  
FAAH rs324420 Nonsynonymous 0.25 0.21 0.19 45

Abbreviations: AIWG, antipsychotic-induced weight gain; CNR, cannabinoid receptor; MAF, minor allele frequency; SNP, single-nucleotide polymorphism; UTR, untranslated region.

a

FTO SNPs removed from analysis due to near perfect linkage disequilibrium with rs1121980.

b

rs806378 maps to either a promoter, 5′UTR, or intronic location in alternatively processed CNR1 transcripts. Bolded P-values are significant after Bonferroni-correction for 19 tests.