Skip to main content
. 2013 Jun 18;3(6):e271. doi: 10.1038/tp.2013.46

Table 3. Western blotting results for FMRP, GABRθ, mGluR5 and GABRρ2 values expressed as ratios to β-actin and neuronal-specific enolase (NSE) in lateral cerebellum.

  ANOVA
Control
Schizophrenia
Bipolar disorder
Major depression
  F P Protein P Protein P Protein P Protein P
GABRθ/β-actin 5.49 0.003 0.425±0.105 RG 0.231±0.136 0.001 0.297±0.090 0.012 0.301±0.138 0.014
GABRρ2/β-actin 2.90 0.047 0.023±0.013 RG 0.048±0.042 NC 0.047±0.014 0.0044 0.058±0.038 0.0085
mGluR5 dimer/β-actin 2.14 NC 0.176±0.111 RG 0.125±0.10 NC 0.127±0.101 NC 0.211±0.064 NC
mGluR5 monomer/β-actin 4.15 0.011 0.038±0.030 RG 0.015±0.023 0.05 0.0086±0.0098 0.001 0.019±0.020 NC
FMRP/β-actina 6.22 0.001 0.070±0.052 RG 0.017±0.029 0.039 0.029±0.033 0.014 0.023±0.021 0.005
β-actin 0.83 NC 25.8±2.07 RG 25.2±2.07 NC 26.9±2.91 NC 26.1±4.38 NC
GABRθ/NSE 5.61 0.002 0.87±0.18 RG 0.48±0.30 0.001 0.58±0.20 0.005 0.62±0.24 0.012
GABRρ2/NSE 3.05 0.039 0.045±0.025 RG 0.1±0.094 NC 0.096±0.052 0.009 0.13±0.085 0.006
mGluR5 dimer/NSE 1.99 NC 0.32±0.20 RG 0.26±0.23 NC 0.26±0.22 NC 0.44±0.12 NC
mGluR5 monomer/NSE 5.18 0.004 0.08±0.48 RG 0.032±0.049 0.03 0.017±0.021 0.004 0.041±0.041 0.047
FMRP/NSE 4.93 0.004 0.092±0.07 RG 0.023±0.04 0.001 0.042±0.05 0.003 0.033±0.033 0.001
NSE 0.93 NC 20.2±3.34 RG 20.1±1.67 NC 20.2±3.24 NC 21.6±2.87 NC

Abbreviations: ANOVA, analysis of variance; NC, no change; RG, reference group.

a

FMRP data reprinted from Schizophrenia Research, 124(1–3):246-247, Fatemi, S.H., Kneeland, R.E., Liesch, S.B., Folsom, T.D., Fragile X mental retardation protein levels are decreased in major psychiatric disorders, page 246, Copyright (2010), with permission from Elsevier.

Bold values indicate significant (P<0.05) values.