Table 3. Western blotting results for FMRP, GABRθ, mGluR5 and GABRρ2 values expressed as ratios to β-actin and neuronal-specific enolase (NSE) in lateral cerebellum.
|
ANOVA |
Control |
Schizophrenia |
Bipolar disorder |
Major depression |
||||||
|---|---|---|---|---|---|---|---|---|---|---|
| F | P | Protein | P | Protein | P | Protein | P | Protein | P | |
| GABRθ/β-actin | 5.49 | 0.003 | 0.425±0.105 | RG | 0.231±0.136 | 0.001 | 0.297±0.090 | 0.012 | 0.301±0.138 | 0.014 |
| GABRρ2/β-actin | 2.90 | 0.047 | 0.023±0.013 | RG | 0.048±0.042 | NC | 0.047±0.014 | 0.0044 | 0.058±0.038 | 0.0085 |
| mGluR5 dimer/β-actin | 2.14 | NC | 0.176±0.111 | RG | 0.125±0.10 | NC | 0.127±0.101 | NC | 0.211±0.064 | NC |
| mGluR5 monomer/β-actin | 4.15 | 0.011 | 0.038±0.030 | RG | 0.015±0.023 | 0.05 | 0.0086±0.0098 | 0.001 | 0.019±0.020 | NC |
| FMRP/β-actina | 6.22 | 0.001 | 0.070±0.052 | RG | 0.017±0.029 | 0.039 | 0.029±0.033 | 0.014 | 0.023±0.021 | 0.005 |
| β-actin | 0.83 | NC | 25.8±2.07 | RG | 25.2±2.07 | NC | 26.9±2.91 | NC | 26.1±4.38 | NC |
| GABRθ/NSE | 5.61 | 0.002 | 0.87±0.18 | RG | 0.48±0.30 | 0.001 | 0.58±0.20 | 0.005 | 0.62±0.24 | 0.012 |
| GABRρ2/NSE | 3.05 | 0.039 | 0.045±0.025 | RG | 0.1±0.094 | NC | 0.096±0.052 | 0.009 | 0.13±0.085 | 0.006 |
| mGluR5 dimer/NSE | 1.99 | NC | 0.32±0.20 | RG | 0.26±0.23 | NC | 0.26±0.22 | NC | 0.44±0.12 | NC |
| mGluR5 monomer/NSE | 5.18 | 0.004 | 0.08±0.48 | RG | 0.032±0.049 | 0.03 | 0.017±0.021 | 0.004 | 0.041±0.041 | 0.047 |
| FMRP/NSE | 4.93 | 0.004 | 0.092±0.07 | RG | 0.023±0.04 | 0.001 | 0.042±0.05 | 0.003 | 0.033±0.033 | 0.001 |
| NSE | 0.93 | NC | 20.2±3.34 | RG | 20.1±1.67 | NC | 20.2±3.24 | NC | 21.6±2.87 | NC |
Abbreviations: ANOVA, analysis of variance; NC, no change; RG, reference group.
FMRP data reprinted from Schizophrenia Research, 124(1–3):246-247, Fatemi, S.H., Kneeland, R.E., Liesch, S.B., Folsom, T.D., Fragile X mental retardation protein levels are decreased in major psychiatric disorders, page 246, Copyright (2010), with permission from Elsevier.
Bold values indicate significant (P<0.05) values.