Table 1.
Antimycobacterial, cytotoxic and anti-infective activities of commercially available 2-arylpropanoic acids (1–9)
| MIC values against Mycobacterium (mg/L) | MIC values against M neoaurum in Sauton's agar (mg/L) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| M tuberculosis H37Rv | M bovis BCG | M aurum | M neoaurum | pH=5.8 | pH=7.0 | Cytotoxicity GIC50 (mg/L) RAW264.7 | Selectivity index SI (GIC50/MIC) | MIC values (mg/L) against M aurum grown inside RAW264.7 | |
| 1 | 75 | 90 | 65 | 65 | 20 | 200 | 1000 | 13.3 | 100 |
| 2 | 90 | >100 | >100 | >100 | 50 | >200 | 1000 | 11.1 | >100 |
| 3 | 100 | >100 | 100 | >100 | 20 | 200 | 1000 | 10 | 100 |
| 4 | >100 | >100 | >100 | >100 | 65 | >200 | 1000 | <10 | >100 |
| 5 | 90 | 70 | 70 | 65 | 20 | 70 | 1000 | 11.1 | >100 |
| 6 | >100 | >100 | 90 | >100 | 50 | >200 | 1000 | <10 | >100 |
| 7 | 40 | 65 | 40 | 40 | 20 | 40 | 1000 | 25 | 390 |
| 8 | 70 | Nd | Nd | Nd | Nd | Nd | 1000 | 14.3 | Nd |
| 9 | >100 | Nd | Nd | Nd | Nd | Nd | 1000 | <10 | Nd |
| RIF | 0.05 | 0.05 | 0.1 | 1 | 0.4 | 0.4 | 700 | 60 000 | 0.4 |
| INH | 0.05 | 0.1 | 0.4 | 2 | 0.4 | 1.6 | 3000 | 14 000 | 0.4 |
Nd, not determined.
INH, isoniazid; MIC, minimum inhibitory concentration; RIF, rifampin.