Table 1.
Pharmacokinetic parameters of fluticasone furoate and fluticasone propionate following intravenous administration
| Parameter (units) | Fluticasone furoate 250 μg | Fluticasone propionate 250 μg | ||
|---|---|---|---|---|
| Geometric mean (95 % CI) | CV (%) | Geometric mean (95 % CI) | CV (%) | |
| AUC∞ (pg·h/mL) | 3,484 (3,136, 3,870) | 21 | 3,910 (3,464, 4,413) | 21 |
| t½β (h) | 13.6 (10.6, 17.6) | 42 | 14.0 (10.4, 18.9) | 58 |
| CL (L/h) | 71.8 (64.6, 79.7) | 22 | 63.9 (56.7, 72.2) | 22 |
| Vss (L) | 704 (543, 914) | 47 | 577 (453, 736) | 48 |
AUC ∞ area under the plasma concentration–time curve from time zero to infinity, CL clearance, CV coefficient of variation, t ½β terminal elimination half-life, V ss volume of distribution at steady state