Table 3.
Summary of parameters devised from deconvolution analysis
Parameter | FF 2,000 μg: formulation 1 | FF 2,000 μg: formulation 2 | FF 2,000 μg: formulation 3 | FP 1,000 μg |
---|---|---|---|---|
t½abs (h) | 12.1 (10.2, 14.3) | 10.1 (8.57, 11.8) | 10.7 (8.92, 12.8) | 4.81 (3.20, 7.22) |
T90 (h) | 31.7 (25.4, 39.6) | 23.4 (19.1, 28.6) | 19.1 (15.2, 23.9) | 10.5 (1.67, 14.4) |
Values are expressed as geometric means (90 % CI)
FF fluticasone furoate, FP fluticasone propionate, T90 time for 90 % of the drug to be absorbed, t ½abs absorption half-life