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. Author manuscript; available in PMC: 2013 Jun 26.
Published in final edited form as: Biol Pharm Bull. 2012;35(10):1761–1764. doi: 10.1248/bpb.b12-00419

Table I.

Compound Promastigote
Killing (IC50)		 Amastigote
Killing**
(IC50)		 Macrophage
cytotoxicity§
(CC50)		 In vitro
Therapeutic
Index§§
SSG 306.8 + 5.06 13.32 + 5.14 53.4 + 1 4
TR 001 5.4 + 2.4Π 0.069 + 0.02Π 46.5 + 2 659
TR 002 7.04 + 0.15Π 0.26 + 0.18Π 49.2 + 2.7 189.2

IC50 is the concentration of drug (µM) to achieve 50% killing of parasites per 106 axenic promastigotes or 2.5 × 106 amastigotes inside of 0.5 × 106 BMDM after 48 h of culture.

§

Drug concentration (µM) per 0.5 × 106 BMDM to achieve 50% killing of macrophages.

§§

Therapeutic index = CC50/IC50**.

Π

significantly different (p<0.05) as compared to SSG.