TABLE 4.

Univariate Proportional Hazards Models Predicting First Culture Positive for Mucoid P. aeruginosa

Covariate	Comparison	RH	95% CI	P-value
Gender	Male vs. female	0.60	(0.43, 0.83)	0.002
DF508 alleles	1 or 2 vs. 0	1.54	(0.98, 2.41)	0.06
Culture history
S. aureus	Ever vs. never +	0.38	(0.25, 0.58)	<0.0001
S. aureus	Recent + vs. –	0.23	(0.17, 0.32)	<0.0001
BCC	Ever vs. never +	1.32	(0.61, 2.86)	0.48
BCC	Recent + vs. –	0.64	(0.16, 2.63)	0.54
S. maltophilia	Ever vs. never +	1.58	(0.97, 2.57)	0.07
S altophilia	Recent + vs. —	1.24	(0.44, 3.51)	0.69
Lung function
FEV1 %	10% points ↓	1.20	(1.11, 1.30)	<0.0001
FEV1 liters	1 L ↓	1.75	(1.32, 2.30)	<0.0001
FVC %	10% points	1.19	(1.09, 1.30)	0.0001
FVC liters	↓ 1 L ↓	1.56	(1.22, 2.01)	0.0004
FEF25–75 %	10% points	1.12	(1.05, 1.18)	0.0002
FEF25–75 liters	↓ 1 L ↓	1.40	(1.16, 1.70)	0.0005
Blood counts
WBC count	Twofold ↑	1.20	(0.85, 1.68)	0.30
Lymphocyte count	Twofold ↑	1.13	(0.83, 1.55)	0.43
Lymphocyte %	10% points ↑	0.95	(0.80, 1.13)	0.55
Neutrophil count	Twofold ↑	1.26	(0.97, 1.63)	0.09
Neutrophil %	10% points ↑	1.05	(0.90, 1.22)	0.57
Eosinophil count	Twofold ↑	1.00	(0.86, 1.16)	0.99
Eosinophil %	1% point ↑	1.00	(0.92, 1.09)	0.95
Other markers
AAT	Twofold ↑	1.65	(0.98, 2.77)	0.06
Albumin	1 g/dl ↑	0.77	(0.51, 1.17)	0.22
CRP	Twofold ↑	1.01	(0.95, 1.08)	0.70
Total protein	1 g/dl ↑	0.81	(0.63, 1.03)	0.09
IgA	Twofold ↑	1.05	(0.89, 1.25)	0.55
IgG	Twofold ↑	1.10	(0.76, 1.59)	0.62
IgM	Twofold ↑	1.04	(0.84, 1.31)	0.70
Vitamin A	1 mcg/dl ↑	0.98	(0.97, 0.99)	0.008
Vitamin E	1 mg/L ↑	0.96	(0.93, 1.00)	0.08

RH, relative hazard; CI, confidence interval; BCC, Burkholderia cepacia complex; FEV1, forced expiratory volume in 1 sec; FVC, forced vital capacity; FEF_25–75, mid peak flows.