Table 1.

Effects of ID93/GLA-SE Immunotherapy on Lung Pathology of Mycobacterium tuberculosis–Infected SWR/J

Groupa	Lesion Grade	Lung (%)b	Lung AFBc	Granuloma structure	Diagnosis
Mock (Day 106)	3–4 Moderate-Marked	40–100	6–30	Coalescing macrophage nodules, with syncytial giant cells	Histiocytic alveolar and interstitial pneumonia, moderate to marked; granulomatous lobar bronchopneumonia.
					Numerous AFB in lesions
Rxd (Day 106)	0–2 Mild-Moderate	0%–40%	<1	No nodular granulomas, Few macrophages	Histiocytic alveolar and interstitial pneumonia, mild to moderate.
				Resolution of large lesions	Minimal AFB in lesions
Rxd (Day 241, 295)	4 Marked	41–100	≤30	No significant histiocytic granulomas, no syncytial macrophages	Histiocytic alveolar and interstitial pneumonia, marked.
					Many AFB in lesions
Rxd + ID93/GLA-SEe (Day 241)	2 Mild-Moderate	11–40	≤6	Histiocytic granulomas with syncytial macrophages	Histiocytic alveolar and interstitial pneumonia, mild-moderate.
				Several small dense lymphoid aggregates	Few or no AFB in lesions
Rxf + ID93/GLA-SEe (Day 295)	1–3 Minimal-Moderate	0–40	≤1–6	Histiocytic granulomas with syncytial macrophages	Histiocytic alveolar and interstitial pneumonia, minimal-moderate.
				Minimal, multifocal, infiltration of lymphocytes	Few AFB in lesions

^a Data are representative of 3–5 animals per group.

^b Percent of lung tissue involved: Minimal (grade 1 or <10%); Mild (grade 2 or 11%–20%); Moderate (grade 3 or 21%–40%); Marked (grade 4 or 41%–100%).

^c Number of AFB/HPF, 600x.

^d 90 day INH/RIF chemotherapy initiated 15 days following infection with M. tuberculosis.

^e Mice were immunized 3 times, 3 weeks apart after the administration of a chemotherapy treatment.

^f 60 day INH/RIF chemotherapy initiated 15 days following infection with M. tuberculosis.