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. 2013 Jan 28;207(9):1471–1479. doi: 10.1093/infdis/jit036

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© The Author 2013. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

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Figure 2. — Cecal ligation and puncture (CLP) decreased the levels of Akt and glycogen synthase kinase G β (GSK3β) phosphorylation was attenuated by CpG oligodeoxynucleotide (CpG-ODN). Mice were treated with CpG-ODN, control CpG-ODN (control-ODN), and inhibitory CpG-ODN (iCpG-ODN) by intraperitoneal injection 1 hour prior to CLP (n = 6/group). Sham surgery served as a sham control (n = 6/group). Hearts were harvested, and cellular proteins were prepared. The levels of phosphorylation of Akt (p-Akt; A) and GSK-3β (p-GSK3β; B) were examined by Western blotting. Representative blots are shown above the graph. Abbreviations: S, Sham; C, CLP; C-ODN, Control-ODN; CpG, CpG-ODN; iCpG, inhibitory CpG-ODN. *P < .05.