Table 3.
Mean (SE) Data for Knee Extensor Strength and Leg Press Power in Men and Women Before and After Weight Loss, According to Main Intervention Arm
| Pioglitazone | No Pioglitazone | RT | No RT | |
|---|---|---|---|---|
| Women | ||||
| Mean KE strength (Nm) | ||||
| Baseline | 56.8 (3.4) | 53.3 (5.2) | 51.2 (4.8) | 59.0 (3.8) |
| Follow-up* | 59.5 (3.3) | 55.9 (3.3) | 61.5 (3.3) | 53.8 (3.5) |
| LS change (95% CI) from baseline* | 3.9 (−1.9, 10.7) | 0.3 (−6.5, 7.1) | 5.9 (−0.8, 12.5) | −1.7 (−8.7, 5.3) |
| Between-group difference*,† (95% CI) | 3.6 (−6.1, 13.2); p = .45 | 7.6 (−2.2, 17.4); p = .12 | ||
| Mean LP power (W) | ||||
| Baseline | 41.8 (4.2) | 47.8 (5.5) | 38.0 (4.2) | 51.6 (5.1) |
| Follow-up* | 71.1 (4.7) | 62.8 (4.8) | 81.6 (4.7) | 52.3 (4.9) |
| LS change (95% CI) from baseline* | 26.0 (16.5, 35.5) | 17.7 (7.9, 27.4) | 36.5 (26.8, 46.1) | 7.2 (−2.7, 17.1) |
| Between-group difference*,† (95% CI) | 8.3 (−5.3, 22.0); p = .22 | 29.3 (15.2, 43.4); p < .001 | ||
| Men | ||||
| Mean KE strength (Nm) | ||||
| Baseline | 109.3 (6.1) | 106.9 (5.5) | 112.9 (7.4) | 103.4 (3.6) |
| Follow-up* | 102.9 (6.4) | 108.0 (6.2) | 103.1 (6.3) | 107.7 (6.4) |
| LS change (95% CI) from baseline* | −8.0 (−20.9, 5.0) | −2.9 (−15.5, 9.7) | −7.8 (−20.5, 5.0) | −3.1 (−16.1, 9.9) |
| Between-group difference*,† (95% CI) | −5.1 (−23.1, 13.0); p = .58 | −4.7 (−23.0, 13.7); p = .61 | ||
| Mean LP power (W) | ||||
| Baseline | 104.3 (7.2) | 92.9 (8.2) | 96.0 (7.3) | 101.2 (8.3) |
| Follow-up* | 107.2 (8.7) | 121.8 (8.7) | 124.5 (8.5) | 104.5 (8.9) |
| LS change (95% CI) from baseline* | 7.4 (−10.2, 25.0) | 22.0 (4.4, 39.5) | 24.7 (7.5, 41.8) | 4.6 (−13.3, 22.6) |
| Between-group difference*,† (95% CI) | −14.6 (−39.6, 10.4); p = .25 | 20.0 (−4.9, 45.0); p = .11 | ||
Note. LP, leg press; KE, knee extensor; RT, resistance training; CI, confidence interval; LS, least squares.
*Follow-up means, measures of change, and between-group differences are adjusted for main effects and baseline measure.
†Differences are change in treatment group minus change in control group.