Table 3.

Mean (SE) Data for Knee Extensor Strength and Leg Press Power in Men and Women Before and After Weight Loss, According to Main Intervention Arm

	Pioglitazone	No Pioglitazone	RT	No RT
Women
Mean KE strength (Nm)
Baseline	56.8 (3.4)	53.3 (5.2)	51.2 (4.8)	59.0 (3.8)
Follow-up*	59.5 (3.3)	55.9 (3.3)	61.5 (3.3)	53.8 (3.5)
LS change (95% CI) from baseline*	3.9 (−1.9, 10.7)	0.3 (−6.5, 7.1)	5.9 (−0.8, 12.5)	−1.7 (−8.7, 5.3)
Between-group difference*,† (95% CI)	3.6 (−6.1, 13.2); p = .45		7.6 (−2.2, 17.4); p = .12
Mean LP power (W)
Baseline	41.8 (4.2)	47.8 (5.5)	38.0 (4.2)	51.6 (5.1)
Follow-up*	71.1 (4.7)	62.8 (4.8)	81.6 (4.7)	52.3 (4.9)
LS change (95% CI) from baseline*	26.0 (16.5, 35.5)	17.7 (7.9, 27.4)	36.5 (26.8, 46.1)	7.2 (−2.7, 17.1)
Between-group difference*,† (95% CI)	8.3 (−5.3, 22.0); p = .22		29.3 (15.2, 43.4); p < .001
Men
Mean KE strength (Nm)
Baseline	109.3 (6.1)	106.9 (5.5)	112.9 (7.4)	103.4 (3.6)
Follow-up*	102.9 (6.4)	108.0 (6.2)	103.1 (6.3)	107.7 (6.4)
LS change (95% CI) from baseline*	−8.0 (−20.9, 5.0)	−2.9 (−15.5, 9.7)	−7.8 (−20.5, 5.0)	−3.1 (−16.1, 9.9)
Between-group difference*,† (95% CI)	−5.1 (−23.1, 13.0); p = .58		−4.7 (−23.0, 13.7); p = .61
Mean LP power (W)
Baseline	104.3 (7.2)	92.9 (8.2)	96.0 (7.3)	101.2 (8.3)
Follow-up*	107.2 (8.7)	121.8 (8.7)	124.5 (8.5)	104.5 (8.9)
LS change (95% CI) from baseline*	7.4 (−10.2, 25.0)	22.0 (4.4, 39.5)	24.7 (7.5, 41.8)	4.6 (−13.3, 22.6)
Between-group difference*,† (95% CI)	−14.6 (−39.6, 10.4); p = .25		20.0 (−4.9, 45.0); p = .11

Note. LP, leg press; KE, knee extensor; RT, resistance training; CI, confidence interval; LS, least squares.

^*Follow-up means, measures of change, and between-group differences are adjusted for main effects and baseline measure.

^†Differences are change in treatment group minus change in control group.