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. Author manuscript; available in PMC: 2013 Jun 26.
Published in final edited form as: Mol Cancer Ther. 2009 Jun 9;8(6):1570–1578. doi: 10.1158/1535-7163.MCT-08-1079

Figure 3. Effect of dietary delivery of α-TEA on the growth of spontaneously developing mammary tumors.

Figure 3

MMTV-PyMT mice (10 mice) received α-TEA in the diet (0.1%) starting at 6 weeks of age (day 42) until 15 weeks of age (day 105) when mice were sacrificed. Untreated mice (9 mice) received control diet throughout the study. (A) The values represent the cumulative tumor areas per mouse. Tumor growth curves were determined by non-linear regression analysis and statistically evaluated for differences by f-test. (B) The values represent tumor multiplicity calculated as: Tumor multiplicity = [# tumors per group] / [# of mice per group]. (C) Effect of dietary α -TEA on tumor spread. Tumor-bearing MMTV-PyMT mice from the above study were sacrificed on day 105. To determine the number of pulmonary metastases, lungs were inflated with India ink and the surface lung metastases were counted. Boxed numbers are the mean numbers of lung metastases per group ± SEM. Differences were evaluated by Mann-Whitney test.