Table 2.

Ongoing clinical trials with curcumin

Trial type	Official title	Cancer type		Identifier number
Phase 1 Non-randomized	Phase I Study of Surface-Controlled Water Soluble Curcumin (THERACURMIN CR-011L) in Patients With Advanced Malignancies	Advanced malignancies	Safety/Efficacy Study Single Group Assignment Open Label	NCT 01201694
Phase 1 Non-randomized	Phase I Pharmacokinetic Trial of Curcuminoids Administered in a Capsule Formulation	Colon cancer	Pharmacokinetics study Single Group Assignment Open Label	NCT 00027495
Phase 1 Randomized controlled trial Recruiting	Phase I Clinical Trial Investigating the Ability of Plant Exosomes to Deliver Curcumin to Normal and Malignant Colon Tissue	Colon cancer	Bioavailability Study Factorial Assignment Open Label	NCT 01294072
Phase 1 Randomized controlled trial	Crossover, Multiple Dose Pharmacokinetics of Two Curcumin Formulations in Healthy Volunteers	Healthy volunteers	Pharmacokinetics Study Crossover Assignment Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor)	NCT 01330810
Phase 1 Non-randomized	Curcumin Chemoprevention of Colorectal Neoplasia (Curcumin biomarker)	Colorectal cancer	Pharmacodynamics Study Single Group Assignment Intervention Open Label	NCT 01333917
Phase 1 Randomized controlled trial	Pilot Study of Curcumin, Vorinostat, and Sorafenib in Patients With Advanced Solid Tumors	Advanced solid tumor	Safety/Efficacy Study Single Group Assignment Open Label	NCT 01608139
Phase 2 Randomized controlled trial	Phase II Double Blind Placebo-Controlled Trial of Curcuminoids’ Effect on Cellular Proliferation, Apoptosis and COX-2 Expression in the Colorectal Mucosa of Subjects With Recently Resected Sporadic Adenomatous Polyps	Colorectal cancer	Safety/Efficacy Study Parallel Assignment Double Blind (Subject, Investigator)	NCT 00118989
Phase 2 Non-randomized	Phase II Trial of Curcumin in Cutaneous T-cell Lymphoma Patients	Cutaneous T-Cell Lymphoma	Efficacy Study Single Group Assignment Open Label.	NCT 00969085
Phase 2 Non-randomized	Phase II Trial of Curcumin in Patients With Advanced Pancreatic Cancer	Advanced pancreatic cancer	Safety/Efficacy Study Single Group Assignment Open Label.	NCT 00094445
Phase 2 Randomized controlled trial Recruiting	Curcumin for Treatment of Intestinal Adenomas in Familial Adenomatous Polyposis (FAP)	Colorectal cancer	Parallel Assignment Double Blind (Subject, Investigator)	NCT 00641147
Phase 2 Randomized controlled trial	Curcumin With Pre-operative Capecitabine and Radiation Therapy Followed by Surgery for Rectal Cancer	Rectal cancer	Safey/Efficacy Study Single group Assignment Double Blind (Subject, Caregiver)	NCT 00745134