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. Author manuscript; available in PMC: 2013 Jun 26.
Published in final edited form as: NMR Biomed. 2011 May 23;24(10):1380–1391. doi: 10.1002/nbm.1701

Fig. 1.

Fig. 1

A schematic overview of the Single Infusion Protocol. In vitro calibrations (upper panel) are used to define a relationship between the molar relaxivity of GdDOTA-4AmP and pH. In vivo calibrations (lower panel) involve co-injection of pH-independent Gd- DTPA and Dy-DOTP. These data are used to define an in-vivo relationship between [Gd] and the EPSI-measured linewidth. In the in vivo pHe experiment (middle panel), the linewidth induced by the co-injected [Dy] is used to calculate the per-pixel [Gd-DOTA-4AmP], which is then combined with T1 values to calculate a molar relaxivity and hence, pH.