Table 1.
Subject Characteristics (n=331)
| Parameter | Median (Q1, Q3) or Percent |
|---|---|
| Age (years) | 36 (28, 45) |
| Sex | 89% Male, 11% Female |
| Race/ethnicitya | 44% White, 32% Black, 20% Hispanic |
| Smoking statusa | 38% Current, 40% Never |
| Alcohol Use (≥ 3/drinks per day)a | 29% |
| Current Proton Pump Inhibitor Use | 6% |
| Physical Activitya | 23% Low, 60% Moderate, 18% High |
| HIV-1 RNA (log10 copies/mL) | 4.5 (4.0, 5.1) |
| CD4+ cell count (/mm3) | 349 (207, 455) |
| Time since HIV diagnosis (months) | 5.7 (2.4 - 31.5) |
| Prior AIDS | 23% |
| Nadir CD4 cell count (/mm3) | 311 (195, 417) |
| Hepatitis C | 7% |
| Body Composition | |
| Body-mass index (kg/m2) | 25 (22, 28) |
| Visceral Adipose Tissue (cm2) | 73 (39, 107) |
| Total body fat mass (kg) | 17 (11, 24) |
| Total body lean mass (kg) | 56 (50, 63) |
| Biomarkers | |
| C-reactive protein(mg/L) | 1.4 (0.7, 3.0) |
| Interleukin-6 (pg/mL) | 1.8 (1.2, 3.0) |
| Adiponectin (ng/mL) | 7780 (5355, 11540) |
| Leptin (pg/mL) | 5288 (3017, 9558) |
| OPG (pmol/L) | 4.2 (3.3, 5.1) |
| RANKL (pg/mL) | 34 (16, 57) |
| Bone Parameters | |
| Lumbar Spine T-score | −0.5 (−1.2, 0.3) |
| Lumbar Spine Z-score | −0.4 (−1.2, 0.4) |
| Lumbar Spine Z-score ≤ −2 N (%)a | 29 (9%) |
| Total Hip T-score | −0.3 (−0.8, 0.4) |
| Total Hip Z-score | −0.1 (−0.6, 0.6) |
| Total Hip Z-score ≤ −2.0 a | 4 (1%) |
| Femoral Neck T-score | −0.5 (−1.1, 0.2) |
| Femoral Neck Z-score | −0.1 (−0.7, 0.5) |
| Femoral Neck Z-score ≤ −2 a | 7 (2%) |
a
Percentages are calculated for participants with data; 1 participant is missing race/ethnicity, 1 participant is missing smoking history; 28 participants are missing alcohol use; 14 participants are missing physical activity; 9 participants are missing hip and femoral neck BMD Z scores; and 7 participants are missing lumbar spine BMD Z scores.