Table 4.
Published HRr series with local control and toxicity data
| Series | N (patients/metastases) | Lesion size(median) | Fractionation | Local control | Reported toxicity |
|---|---|---|---|---|---|
|
Aoki et al. [[7]] |
44/65 |
- |
5-6 Gy x 3-5 |
72% at 1 year |
2% grade 3 |
|
Aoyama et al. [[8]] |
87/159 |
3.3 cc |
8.75 Gy x 4 |
81% at 1 year |
7% grade 3 |
|
DePotter et al. [[9]] |
35/58 |
8.6 cc |
WBRT + 6 Gy x 5 |
66% at 1 year |
11% grade 3 |
|
Fahrig et al. [[17]] |
150/228 |
6.1 cc |
6-7 Gy x 5 |
- |
22% |
| 5 Gy x 7 |
- |
7% |
|||
| 10 Gy x 4 |
- |
0% |
|||
|
Giubilei et al. [[10]] |
30/44 |
2.1 cm/4.8 cc |
6 Gy x 3/ 8 Gy x 4 |
86% at 1 year |
- |
|
Kwon et al. [[11]] |
27/52 |
1.2 cm/0.5 cc |
20-35 Gy in 4-6 |
68% at 1 year |
5.8% radiation necrosis |
|
Lindvall et al. [[12]] |
47/47 |
- |
8 Gy x 5 |
84% crude |
6.25% radiation necrosis, 1 patient death |
|
Narayana et al. [[13]] |
20/20 |
- |
6 Gy x 5 |
70% at 1 year |
15% |
|
Ogura et al. [[14]] |
39/46 |
1.8 cm |
7 Gy x 5 or |
17% at 1 year |
2.5% grade 3 |
| WBRT + 4-5 Gyx5 | |||||
|
Wang et al. [[15]] |
37/37 |
cavity > 3 cm |
8 Gy x 3 |
80% at 6 months |
9% |
| Current Study | 42/42 | 3.9 cm/13.6 cc | 5-8 Gy x 3-5 | 62% at 1 year | 7% radiation necrosis |