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. Author manuscript; available in PMC: 2013 Jun 26.
Published in final edited form as: Pulm Pharmacol Ther. 2009 Aug;22(4):311–317. doi: 10.1016/j.pupt.2009.01.006

Fig. 4.

Fig. 4

Vascular reactivity. Endothelin-1-induced pulmonary vasoconstriction in sham- and MCT-treated rats (A). Endothelin-1-induced pulmonary vasoconstriction in the presence of an ETA-R antagonist (open triangle, 10 nmol 1−1), an ETB-R antagonist (filled circles, 1 μmol l−1) and the dual antagonist Bosentan (filled diamond, 10 μmol l−1) in both sham (B) and MCT rats (C). n = 6–8/group. (D) Endothelin-1-induced vasoconstriction of basilar arteries in the absence and presence of bosentan (filled diamond, 10 μmol l−1). n = 6–8/group. Values are mean ± SEM. *p < 0.001, #p < 0.05.