Table 1. Grading of pathological features.
|
Astrocytes
|
Microglia
|
PrPSc
|
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Structure | ME7 | 79A | 22L | ME7 | 79A | 22L | ME7 | 79A | 22L | ||
| Medial septum/diagonal band | + | ++ | ++/+++ | + | + | ++ | + | ++ | +++ | ||
| Dentate gyrus/CA3 | + | +/++ | 0/+ | + | +/++ | + | +++ | ++ | ++/+++ | ||
| Hippocampus/ CA1 | +/++ | +/++ | 0/+ | ++ | ++ | + | ++ | ++ | + | ||
| Thalamus | ++ | ++ | ++/+++ | +/++ | ++/+++ | ++/+++ | ++ | ++ | ++ | ||
| Dorsal raphe | 0/+ | + | ++ | 0 | 0/+ | +/++ | +/++ | +/++ | +++ | ||
| Median raphe | +/++ | ++ | ++ | + | + | ++ | ++ | ++ | +++ | ||
| Cerebellum, simple lobule | 0 | 0/+ | 0/+ | 0 | 0 | 0/+ | 0 | 0 | 0/+ | ||
Sections were scored as 0, +, ++, or +++ where the pattern/number of astrocytes, microglia or PrPSc in NBH is set to zero and other animalsare presented relative to NBH scores.