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. 2013 Jun 26;8(6):e67954. doi: 10.1371/journal.pone.0067954

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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(A) Kaplan-Meier survival curves for Thrb^PV/PVNcor1^+/+ and Thrb^PV/PVNcor1^ΔID/ΔID mice up 15 months of age. Thrb^PV/PVNcor1^ΔID/ΔID (n = 29) survived significantly longer than Thrb^PV/PVNcor1^+/+ mice (n = 58) (p<0.0001). (B) Thyroids of Thrb^PV/PVNcor1^+/+ and Thrb^PV/PVNcor1^ΔID/ΔID mice at the ages of 5–15 months were dissected and weighed. The data are presented as the ratios of thyroid weight to body weight. The differences between the thyroid weights of Thrb^PV/PVNcor1^+/+ and Thrb^PV/PVNcor1^ΔID/ΔID mice were significant (p<0.0001), as determined by Student’s t-test analysis.