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. 2013 Jun 26;8(6):e67954. doi: 10.1371/journal.pone.0067954

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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(A) Hematoxylin and eosin (H&E) staining of thyroid sections (top and middle rows) and lung sections (bottom row) of Thrb^PV/PVNcor1^+/+ (a, c, and e) and Thrb^PV/PVNcor1^ΔID/ΔID (b, d, and f) mice. Histological sections from tissues of Thrb^PV/PVNcor1^+/+ mice showed evidence of (a) vascular invasion in thyroid (arrow), (c) anaplasia in thyroid (arrows), and (e) metastatic lesions in lung (arrows). Sections of thyroids and lungs from Thrb^PV/PVNcor1^ΔID/ΔID showed blood vessels (b) without vascular invasion (arrow), (d) without anaplasia, and (f) lung without metastatic lesions. (B) Comparison of age-dependent percentage occurrence of capsular invasion (a), vascular invasion (b), anaplasia (c), and lung metastasis (d). The data are expressed as the percentage of occurrence of total mutant mice examined. The symbol “#” indicates 0% occurrence.