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. 2013 Jun 26;8(6):e67954. doi: 10.1371/journal.pone.0067954

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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(A) Nuclear protein extracts were prepared from thyroid tumors of Thrb^PV/PVNcor1^+/+ (lanes 1 and 2) or Thrb^PV/PVNcor1^ΔID/ΔID (lanes 3 and 4) mice. Shown are Western blot analyses of BAX (panel a), PUMA (panel b), cleaved caspase 3 (panel c), PARP and cleaved PARP (panel d), and actin loading control (panel e). (B) Quantitation of the band intensities shown in (A). *p<0.05 Protein abundance of BAX and PUMA (panel a), cleaved caspase 3 and cleaved PARP (panel b) was significantly higher and total PARP (panel b) was lower in the thyroids of Thrb^PV/PVNcor1^ΔID/ΔID mice.