Table 4. The gene signature from the microarray dataset using SamR analysis.
ProbeSetID | GeneSymbol | log2FoldChange | SamR-q-value(%) | SamRposition | DESeqPosition | log2Ratio | adjustedPvalue |
209854 s at | KLK2 | 3.84 | 0 | 1 | 15 | 3.18 | 5.77E-160 |
210339 s at | KLK2 | 3.48 | 0 | 2 | 15 | 3.18 | 5.77E-160 |
205041 s at | ORM1/ORM2 | 3.78 | 0 | 3 | NA | NA | NA |
211689 s at | TMPRSS2 | 3.12 | 0 | 4 | 18 | 2.26 | 8.87E-130 |
222118 at | CENPN | 2.58 | 0 | 11 | 6 | 5.09 | 2.12E-295 |
217875 s at | PMEPA1 | 2.38 | 0 | 13 | 142 | 2.99 | 1.4E-30 |
205862 at | GREB1 | 2.36 | 0 | 14 | 1356 | 1.00 | 0.000149717 |
219049 at | CSGALNACT1 | 2.21 | 0 | 15 | 1061 | 1.81 | 0.0000119 |
205102 at | TMPRSS2 | 2.07 | 0 | 16 | NA | NA | NA |
204583 x at | KLK3 | 1.96 | 0 | 20 | 31 | 1.81 | 1.14E-102 |
204582 s at | KLK3 | 2.02 | 0 | 21 | 31 | 1.81 | 1.14E-102 |
209706 at | NKX3-1 | 1.95 | 0 | 22 | 36 | 2.49 | 2.59E-90 |
219555 s at | CENPN | 1.93 | 0 | 29 | 6 | 5.09 | 2.12E-295 |
204560 at | FKBP5 | 2.04 | 0 | 30 | 2 | 5.08 | 0 |
203196 at | ABCC4 | 1.69 | 0 | 33 | 23 | 2.85 | 5.94E-117 |
221584 s at | KCNMA1 | 1.57 | 0 | 35 | 85 | 2.16 | 2.31E-43 |
204897 at | PTGER4 | 1.62 | 0 | 37 | 671 | 3.53 | 0.000000015 |
211548 s at | HPGD | 1.60 | 0 | 38 | 185 | DIV0! | 3.19E-25 |
220014 at | PRR16 | 1.50 | 0 | 44 | NA | NA | NA |
219476 at | C1orf116 | 1.47 | 0 | 46 | 96 | 1.94 | 5.44E-39 |
203180 at | ALDH1A3 | 1.46 | 0 | 48 | 668 | 1.29 | 1.44E-08 |
210787 s at | CAMKK2 | 1.42 | 0 | 49 | NA | NA | NA |
201110 s at | THBS1 | 1.38 | 0 | 51 | NA | NA | NA |
The list of identifiers and their associated genes extracted from the microarray using SamR analysis and put to the sscMap. 18 out these 23 gene identifiers are also identified as differentially expressed genes (DEGs) by the DESeq analysis on the NGS dataset (Table S1). NA indicates that the corresponding gene was not returned as DEG by DESeq and hence is not found in Table S1. Expression fold change is defined as ratio (stimulated/unstimulated). Note that Dseq reported 0 expression for this gene in the unstimulated state, hence ratio(stimulated/unstimulated) and logratio are not defined. Table S5 also contains the signed ranks of these 23 probesetIDs in the 6 instances of reference profiles for cotinine.