Figure 9. CLOCK, SCREB and XBP1 transcriptional regulators, predicted to have altered activities in TBL20 that are reversed in the presence of BW720c, have target genes in common.

Illustration of the target gene network from our analysis where differential expression may result from activation or inhibition of 3 transcription regulators, CLOCK, SCREB and XBP1, each with activation status predicted to be altered by parasite infection and reversed by BW720c in our analysis (see text). Red means up-regulated in TBL20 compared to BL20 (range 1.7–117 fold); green is down-regulated in TBL20 (range 1.7–110 fold); grey, no differential expression.