Fig. 1.

Changes in scores for clinical characteristics and functional parameters. (A) The modified CADESI scores improved after 2 and 4 weeks of treatment with a moisturizer containing physiologic lipids. (B) The PICAD scores for most canine participants showed gradual improvement over time. (C) TEWL decreased significantly after application of the moisturizer. (D) Skin hydration was increased more than four-fold at both 2 and 4 weeks after moisturizer application. (E) TEM scores for day 0 differed significantly from those for day 28 of moisturizer application. Results are presented as the mean ± SD. ^*p < 0.001.