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. Author manuscript; available in PMC: 2013 Nov 1.
Published in final edited form as: Immunol Rev. 2012 Nov;250(1):102–119. doi: 10.1111/j.1600-065X.2012.01161.x

Fig. 1. Structure of N15 TCRαβ ectodomains in complex with an Fab fragment of the H57 mAb.

Fig. 1

(A) The complex structure with H57 bound to the protruding FG loop of the N15 Cβ domain (adapted from 37). (B) The structure of the N15 αβ ectodomains. The α and β subunits are represented in the same color as in (A). The inset offers the detailed internal structure of the Cβ FG loop. (C) The structure of H57 Fab fragment. Note the overall narrow shape of the Fab in comparison to the TCRαβ. The β strands and the CDR2 loop of VL domain are labeled for comparison with that of the N15 Vα domain depicted in (B).