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. Author manuscript; available in PMC: 2013 Nov 1.
Published in final edited form as: Immunol Rev. 2012 Nov;250(1):102–119. doi: 10.1111/j.1600-065X.2012.01161.x

Fig. 4. Structure of a TCR/pMHCII complex, the scD10-CA/I-Ak (PDB 1D9K).

Fig. 4

(A) The complex structure with TCR V module in green (Vα) and cyan (Vβ), MHCII in yellow (α subunit) and orange (β subunit) and CA peptide in magenta. The N- and C- termini of the TCR contacting portion of the peptide are indicated by the P-1 and P8 labels, respectively. (B) The peptide-binding groove of I-Ak is illustrated. The side chain of conserved residues from MHC α and β subunits make extensive hydrogen bonds to the main chain of the peptide such that the 16 amino acid residue peptide adopts a fixed extended conformation on the groove.