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. Author manuscript; available in PMC: 2013 Nov 1.
Published in final edited form as: Immunol Rev. 2012 Nov;250(1):102–119. doi: 10.1111/j.1600-065X.2012.01161.x

Fig. 5. Absence of intrinsic structural differences between the two classes of TCR as well as MHC molecules among their interacting domains.

Fig. 5

(A) The superposition of the V modules of the D10 TCR (PDB 1D9K) and 2C TCR (PDB 2CKB) in Cα is shown using a Cα atom skeleton drawing. (B) Side view (left panel) and top view (right panel) of superimposed I-Ak (PDB 1D9K) and H2-Kb (PDB 2CKB) molecules represented as ribbon drawings. The two peptide-binding grooves overlay well, despite their very different chemical compositions.