Table 5. Baseline characteristics of patients with long-term OS (i.e., OS ⩾30 months).
Characteristic | Long-term OS (n=215) | Non-long-term OS (n=844) | P-value |
---|---|---|---|
Ethnic origin, % | |||
White | 94 | 81 | 0.0002a |
Non-white | 6 | 15 | |
Missing |
0 |
5 |
|
Risk factors based on published MSKCC data, %b | |||
0 (favourable) | 70 | 31 | <0.0001c |
1–2 (intermediate) | 28 | 42 | |
⩾3 (poor) | 0 | 5 | |
Missing |
1 |
21 |
|
ECOG PS, %d | |||
0 | 75 | 58 | <0.0001c |
1 | 25 | 40 | |
2 |
0 |
3 |
|
Prior nephrectomy, % | |||
Yes | 96 | 74 | <0.0001a |
No | 4 | 19 | |
Missing |
0 |
7 |
|
Prior cytokine, % | |||
Yes | 21 | 29 | 0.0170a |
No | 79 | 71 | |
Missing |
0 |
<1 |
|
Baseline Hgb, %d | |||
⩽LLN | 22 | 44 | <0.0001a |
>LLN | 78 | 56 | |
Missing |
0 |
<1 |
|
Baseline LDH, %d | |||
>1.5 × ULN | 3 | 7 | 0.0078a |
⩽1.5 × ULN | 96 | 78 | |
Missing |
1 |
15 |
|
Baseline-corrected Ca, %d | |||
>10 mg dl−1 | 5 | 19 | <0.0001a |
⩽10 mg dl−1 | 95 | 80 | |
Missing |
0 |
1 |
|
Baseline neutrophils, % | |||
⩽ULN | 97 | 78 | <0.0001e |
>ULN | 2 | 12 | |
Missing |
1 |
10 |
|
Baseline platelets, % | |||
⩽ULN | 96 | 80 | <0.0001a |
>ULN | 4 | 19 | |
Missing | 0 | <1 |
Abbreviations: Ca=calcium; ECOG PS=Eastern Cooperative Oncology Group performance status; Hgb=haemoglobin; LDH=lactate dehydrogenase.
Pearson χ2 test for general association.
Includes low serum haemoglobin level; elevated corrected serum calcium level; elevated serum lactate dehydrogenase level; poor performance status; and interval of <1 year between diagnosis and sunitinib treatment (Motzer et al, 2002).
Mantel–Haenszel χ2 test for general association.
Risk factor included in the MSKCC prognostic model (Motzer et al, 2002).
Fisher's exact test for general association when sample size requirement of the χ2 test is not met.