Table 3. Cox proportional regression analysis for the prediction of the ‘low- and intermediate-recurrence risk' and the ‘intermediate-recurrence risk' PCa patients' DFS.

	Univariate analysis			Multivariate analysis
Covariant	HR	95% CIa	P-valueb	HR	95% CIa	P-valueb
Low- and intermediate-recurrence risk PCa patients
miR-145
Positive	1.00			1.00
Negative	3.211	1.071–9.622	0.037	4.467	1.268–15.736	0.020
Gleason score	1.067	0.423–2.691	0.890	0.926	0.306–2.801	0.891
Clinical stage	0.711	0.309–1.634	0.422	0.435	0.133–1.419	0.167
PSA	1.101	0.885–1.370	0.386	1.110	0.847–1.428	0.475
Age	1.024	0.944–1.110	0.569	1.021	0.929–1.123	0.666
DRE	1.166	0.404–3.364	0.777	2.820	0.643–12.368	0.169
Intermediate-recurrence risk PCa patients
miR-145
Positive	1.00			1.00
Negative	4.048	1.131–14.479	0.032	4.425	1.112–17.613	0.035
Gleason score	1.235	0.411–3.706	0.707	1.225	0.323–4.646	0.766
Clinical stage	0.707	0.265–1.884	0.488	0.392	0.081–1.900	0.245
PSA	1.143	0.898–1.454	0.278	1.131	0.861–1.485	0.376
Age	1.002	0.916–1.097	0.957	0.986	0.879–1.106	0.812
DRE	1.249	0.380–4.099	0.714	3.205	0.576–17.848	0.169

Abbreviations: CI=confidence interval; DFS=disease-free survival; DRE=digital rectal examination; HR=hazard ratio; PCa=prostate cancer.

^aCI of the estimated HR.

^bTest for trend.