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. 2013 Jun 4;108(12):2505–2515. doi: 10.1038/bjc.2013.262

Figure 1.

Figure 1

Capecitabine and 5-FU metabolism. Enzymes: Carboxyl esterase (CES), deoxycytidine kinase (dCK), deoxycytidine monophosphate deaminase (dCMDA), cytidine deaminase (CDA), thymidine phosphorylase (TP), uridine phosphorylase (UP), dihydropyrimidine dehydrogenase (DPYD), dihydropyrimidinase (DPYS), orotate phosphoribosyltransferase (OPRT), uridine kinase (UK), uridine monophosphate kinase (UMPK), uridine diphosphate kinase (UDPK), ribonucleotide reductase (RNR), thymidine kinase (TK), thymidine synthase (TS), deoxyuridine triphosphatase (DUT), methylene tetrahydrofolate reductase (MTHFR). Metabolites: deoxyfluorocytidine riboside (5′-dFCR), deoxyfluorocytidine monophosphate (5′-dFCMP), deoxyfluorouridine monophosphate (5-FdUMP), deoxyfluorouracil (5′-dFUR), fluorouracil (5-FU), fluorouridine (5-FUridine), fluorouracil monophosphate (5-FUMP), fluorouracil di, tri-phosphate (5-FUDP, 5-FUTP), deoxyfluorouracil di, tri-phosphate (5-FdUDP, 5-FdUTP), deoxyuridine mono, tri –phosphate (dUMP, dUTP), deoxycytidine mono, tri-phosphate (dTMP, dTTP), 5,10-methylenetetrahydrofolate (5,10-MTHF), 5-methyltetrahydrofolate (5-MeTHF), dihydrofolate (DHF), dihydrofluorouracil (DHFU), beta-fluoroureido propionic acid (β-FUPA).