Table 6. Sensitivity, specificity, positive- and negative-predictive values of variant genotypes significantly associated with toxicity.

Variant	Toxicity and grade	Genotype	Sensitivity	Specificity	Positive-predictive value	Negative-predictive value
All fluoropyrimidine-treated patients
c.1601G>A	DMN 3–4	wt vs het	14	100	>99	78
c.1905+1G>A	DMN 3–4	wt vs het	3	100	>99	76
c.2846A>T	DMN 3–4	wt vs het	4	100	>99	77
c.1679T>G	DMN 3–4	wt vs het	1	100	>99	76
c.1601+1905+2846+1679 variant	DMN 3–4	wt vs het+compound het	23	100	>99	80
c.1129-5923C>G	DMN 3–4	wt vs het	6	97	40	76
TYMS 3′-UTR c.1494del6b	DMN 3–4	wt vs hom	47	54	25	76
TYMS 3′-UTR c.1494del6b	DMN 3–4	wt vs het and hom	81	9	22	59
Capecitabine-treated patients
CDA c.−92 A>G c.−451C>T	Diarrhoea 2–4	wt vs het and hom	61	58	40	77
MTHFR 1298CC	HF 2–3	wt vs hom	26	96	64	82
MTHFR 1298A>C	HF 2–3	wt vs het and hom	55	49	24	79

Abbreviations: DMN=diarrhoea, mucositis and neutropaenia; HF=hand–foot syndrome; UTR=untranslated region.