Table 3.
Aggressive and non-aggressive behaviors and social instigation
| Compound (mg/kg) | Attack Bite Frequency | Sideways Threat Frequency | Walking Duration (s) | Rearing Duration (s) | ||||
|---|---|---|---|---|---|---|---|---|
|
| ||||||||
| Memantine (n= 7) | NON INST | INST | NON INST | INST | NON INST | INST | NON INST | INST |
| 0.0 | 20.9(3.3) | 24.4(3.4) | 18.0(2.5) | 19(3.4) | 146.6(16.8) | 135.5(10.1) | 23.6(6.7) | 22.5(7.3) |
| 3.0 | 28.1(3.6) | 29.0(5.4) | 19.3(2.5) | 21.6(3.3) | 156.2(14.4) | 161.8(10.4) | 19.7(7.8) | 21.9(5.1) |
| 10.0 | 19.9(3.9) | 14.6(4.1) | 16.3(3.2) | 10.3(2.1)* | 173.4(11.5) | 176.1(20.7)* | 13.2(4.2) | 13.5(4.5) |
| 17.0 | 11.1(3.8) | 6.3(2.1)* | 10.9(3.1) | 4.7(1.6)* | 170.5(18.1) | 188.4(18.6)*# | 4.6(1.3)* | 8.4(2.1) |
| 30.0 | 1.7(.7)* | 0.14(.14)* | 2.4(1.6)* | 0.14(.14)* | 138.5(12.4) | 151.7(12.7) | 7.5(1.6)* | 7.1(2.6) |
| MTEP (n= 11) | ||||||||
| 0.0 | 19.3(2.8) | 27.1(3.0)# | 36.7(4.5) | 49.5(3.5)# | 147.9(7.6) | 132.7(8.2) | 23.3(2.3) | 22.9(2.7) |
| 1.0 | 19.1(3.5) | 25.3(2.4) | 33.1(5.7) | 44.5(3.0) | 126.5(11.2) | 136.0(6.6) | 22.5(5.3) | 25.6(2.1) |
| 3.0 | 18.4(2.4) | 23.0(4.3) | 32.8(4.4) | 37.0(6.7) | 120.4(10.0) | 135.0(11.4) | 17.9(3.9) | 22.1(5.2) |
| 5.6 | 15.2(2.8) | 17.7(2.9) | 25.2(4.2) | 31.5(4.4)* | 119.2(4.5) | 115.4(10.4) | 13.6(1.7) | 29.4(7.0)# |
| LY379268 (n=9) | ||||||||
| 0.0 | 13.9 (1.9) | 25.4 (3.1)# | 27.3 (1.8) | 43.1 (3.6)# | 106.9(6.1) | 111.7(3.0) | 20.0(2.7) | 23.1(1.9) |
| 0.3 | 10.3 (2.2) | 23.6 (5.4)# | 19.5 (2.7) | 35.1 (5.2)# | 102.3(9.5) | 103.2(7.0) | 15.8(2.5) | 21.1(2.5) |
| 1.0 | 7.7 (3.0) | 17.4 (5.8)# | 16.0 (5.1) | 25.9 (7.2)* | 66.5(15.7)* | 67.9(14.0)* | 10.3(3.4) | 9.3(2.6)* |
| 3.0 | 2.8 (1.2) | 5.8 (3.2)* | 4.6 (1.9)* | 11.2 (5.3)* | 25.7(5.0)* | 39.8(10.4)* | 3.7(1.3)* | 13.4(9.2) |
Mean shown with SEM in parentheses
*
p<0.05 statistical significance from vehicle administration
#
p<0.05 statistical significance from non-instigation condition