Table 1.
Effect-size estimates for HLA-DRB1 haplotypes on rheumatoid arthritis risk
| HLA-DRB1 amino acid at position | Odds ratio‡ | Classical HLA-DRB1 alleles§ | |||
|---|---|---|---|---|---|
| 11 | 13 | 71 | 74 | ||
| Val | His | Lys | Ala | 4.44 | *0401 (Shared epitope) |
| Val | His or Phe | Arg | Ala | 4.22 | *0408, *0405, *0404, *1001 (Shared epitope) |
| Leu | Phe | Arg | Ala | 2.17 | *0102, *0101 (Shared epitope) |
| Pro | Arg | Arg | Ala | 2.04 | *1601 |
| Val | His | Arg | Glu | 1.65 | *0403, *0407 |
| Asp | Phe | Arg | Glu | 1.65 | *0901 |
| Val | His | Glu | Ala | 1.43 | *0402 |
| Ser | Ser | Lys | Ala | 1.04 | *1303 |
| Pro | Arg | Ala | Ala | 1 | *1501, *1502 (Reference haplotype) |
| Gly | Tyr | Arg | Gln | 0.91 | *0701 |
| Ser | Ser or Gly | Arg | Ala | 0.88 | *1101, *1104, *1201 |
| Ser | Ser | Arg | Glu | 0.84 | *1401 |
| Leu | Phe | Glu | Ala | 0.73 | *0103 |
| Ser | Gly | Arg | Leu | 0.71 | *0801, *0804 |
| Ser | Ser | Lys | Arg | 0.63 | *0301 |
| Ser | Ser | Glu | Ala | 0.59 | *1102, *1103, *1301, *1302 |
‡
The most common haplotype (ProArgAlaAla, corresponding to HLA-DRB1*1501 and *1502) has been used as reference to calculate odds ratios.
§
The classical shared epitope alleles are indicated. Reproduced from Raychaudhuri et al. Nat. Genet. 44, 291–296 (2012).38 © NPG.