Table 2.
Differences after 3 and 6 months of treatment.
| Variable | Follow-up visit | Simvastatin group | Control group | P |
|---|---|---|---|---|
| Early morning stiffness (min) | 3 month | 0.244 (−5.346; 5.834) | −1.125 (−9.962; 7.712) | 0.63 |
| 6 month | −3.536 (−7.701; 0.628) | −2.25 (−10.804; 6.304) | 0.996 | |
| Tender joint count | 3 month | −3 (−4.894; − 1.106) | −0.225 (−2.591; 2.141) | 0.03 |
| 6 month | −1.414 (−3.513; 0.684) | 1.650 (−1.009; 4.309) | 0.243 | |
| Swollen joint count | 3 month | −0.561 (−1.143; 0.021) | 0.275 (−0.431; 0.981) | 0.068 |
| 6 month | −0.341 (−0.808; 0.125) | 0.050 (−0.425; 0.525) | 0.288 | |
| VAS pain (mm) | 3 month | −1.219 (−8.762; 6.323) | 3.75 (−4.561; 12.061) | 0.888 |
| 6 month | −1.219 (−7.421; 4.982) | 4.500 (−4.745; 13.745) | 0.481 | |
| Patient global assessment (mm) | 3 month | −4.39 (−10.255; 1.475) | 0.25 (−6.084; 6.584) | 0.273 |
| 6 month | −2.926 (−8.714; 2.861) | −5.00 (−13.900; 3.900) | 0.196 | |
| Evaluator global assessment (mm) | 3 month | −7.561 (−10.620; −4.502) | 3 (−0.255; 6.255) | <0.001 |
| 6 month | −8.049 (−12.412; −3.685) | 1.500 (−3.279; 6.279) | 0.007 | |
| HAQ-DI | 3 month | −0.064 (−0.172; 0.043) | −0.122 (−0.288; 0.043) | 0.353 |
| 6 month | −0.153 (−0.283; −0.023) | −0.019 (−0.194; 0.154) | 0.149 | |
| Erythrocyte sedimentation rate (mm/h) | 3 month | −0.926 (−4.653; 2.799) | 2.125 (−2.712; 6.962) | 0.203 |
| 6 month | 2.829 (−1.046; 6.705) | 3.800 (−1.018; 8.618) | 0.751 | |
| C-reactive protein (mg/L) | 3 month | 0.961 (−0.178; −2.101) | 3.767 (1.506; −6.027) | 0.055 |
| 6 month | 1.676 (−0.833; 4.186) | 2.57 (0.641; 4.499) | 0.687 | |
| DAS28 ESR | 3 month | −0.56 (−0.849; −0.270) | 0.076 (−0.312; 0.465) | 0.009 |
| 6 month | −0.313 (−0.641; 0.013) | 0.073 (−0.391; 0.537) | 0.171 | |
| DAS28 CRP | 3 month | −0.484 (−0.771; −0.196) | 0.090 (−0.309; 0.491) | 0.02 |
| 6 month | −0.295 (−0.637; 0.045) | 0.098 (−0.334; 0.531) | 0.151 | |
| SDAI | 3 month | −4.708 (−6.889; −2.527) | 0.951 (−2.061; 3.963) | 0.003 |
| 6 month | −2.466 (−5.257; 0.324) | 1.807 (−1.939; 5.553) | 0.067 | |
| CDAI | 3 month | −4.805 (−6.972; −2.637) | 0.575 (−2.397; 3.547) | 0.004 |
| 6 month | −2.634 (−5.355; 0.086) | 1.55 (−2.139; 5.239) | 0.068 | |
| EULAR response | 3 month | 16 (32%) | 7 (14%) | 0.033 |
| 6 month | 15 (30%) | 11 (22%) | 0.364 | |
| Attendance to visit | 3 month | 48 (96%) | 49 (98%) | 0.560 |
| 6 month | 45 (90%) | 43 (86%) | 0.540 |
Between the breaks, there are 95% confidence interval or percents.