Table 1.
Comparisons of baseline characteristics of type 2 diabetes cases and the random subcohort, in the sample and reweighted to the total Women's Health Study cohort
| Crude | Reweighted to Population | |||||
|---|---|---|---|---|---|---|
| Baseline Characteristics | Diabetes Cases N=491 | Reference Subcohort n=561 | P value | Diabetes Cases N=1228 | Reference Subcohort n=19277 | P-value |
| Age, years | 53.3 (49.0, 59.8) | 56.7 (50.9, 64.2) | <0.0001 | 53.6 (49.3, 59.7) | 53.5 (49.2, 59.3) | 0.53 |
| White race, N (%) | 450 (92) | 516 (92) | 0.37 | 1134 (92.4) | 18468 (95.8) | |
| Body mass index, kg/m2 | 29.4 (25.8, 33.9) | 25.6 (23.0, 28.3) | <0.0001 | 29.6 (26.0, 33.9) | 25.6 (22.9, 28.3) | <0.0001 |
| Blood pressure, mm Hg | 135 (125, 145) | 125 (115, 135) | <0.0001 | 135 (125, 145) | 125 (115, 135) | <0.0001 |
| Current smoking, N (%) | 63 (12.9) | 56 (10.0) | 0.18 | 159 (12.9) | 1999 (10.4) | 0.29 |
| Family history of diabetes, N (%) | 208 (42.4) | 158 (28.2) | <0.0001 | 520 (42.3) | 5178 (26.9) | <0.0001 |
| Alcohol use ≥1 drink per day, N (%) | 27 (5.5) | 45 (8.0) | 0.06 | 361 (29.4) | 7749 (40.2) | 0.0001 |
| Exercise ≥1 times per week, N (%) | 159 (32.4) | 259 (46.2) | <0.0001 | 399 (32.5) | 8991 (46.6) | <0.0001 |
| Hormone therapy use, N (%) | 209 (42.7) | 242 (43.3) | 0.60 | 533 (43.5) | 8379 (43.6) | 0.80 |
| Randomized aspirin use, N (%) | 248 (50.5) | 275 (49.0) | 0.66 | 617 (50.2) | 9312 (48.3) | 0.41 |
| eGFR, ml/min/1.73 m2 | 112.5 (92.4, 141.7) | 92.6 (7584, 110.6) | <0.0001 | 112.7 (92.6, 141.7) | 96.1 (80.5, 115.7) | <0.0001 |
| HbA1c, % | 5.3 (5.1, 5.5) | 5.0 (4.9, 5.2) | <0.0001 | 5.3 (5.1, 5.5) | 5.0 (4.8, 5.2) | <0.0001 |
| Fasting insulin, μIU/mL | 12.5 (8.4, 18.9) | 6.8 (4.4, 10.7) | <0.0001 | 12.5 (8.4, 18.8) | 6.9 (4.3, 10.7) | <0.0001 |
| hsCRP, mg/L | 4.0 (2.2, 7.0) | 2.2 (0.9, 4.6) | <0.0001 | 4.1 (2.3, 7.0) | 2.1 (0.9,4.5) | <0.0001 |
| NT-proBNP, ng/L | 46.8 (26.1, 83.2) | 65.2 (37.8, 117.4) | <0.0001 | 46.9 (26.4, 83.1) | 58.7 (35.2, 103.5) | <0.0001 |
| Ln(NT-proBNP) | 3.9 (3.3, 4.4) | 4.2 (3.7, 4.8) | <0.0001 | 3.9 (3.3, 4.4) | 4.1 (3.6, 4.6) | <0.001 |
Abbreviations: eGFR, estimated glomerular filtration rate; HbA1c, glycated hemoglobin; hsCRP, high sensitivity C-reactive protein; NT-proBNP, amino-terminal pro B-type natriuretic peptide.
All values for continuous variables are median (interquartile range).