Table 2.

Spearman correlations between NT-proBNP and other metabolic biomarkers in the reference subcohort, a representative subsample of the Women's Health Study.

	Unadjusted		Age adjusted		Age and BMI adjusted
Characteristic or Biomarker	Rho	P-value	Rho	P-value	Rho	P-value
Age, years	0.371	<0.0001	-	-	-	-
Body mass index, kg/m2	−0.165	<0.0001	−0.185	<0.0001	-	-
Systolic blood pressure, mm Hg	0.059	0.17	−0.044	0.30	0.025	0.57
Metabolic biomarkers
Insulin, μIU/mL	−0.245	<0.0001	−0.248	<0.0001	−0.180	<0.0001
Hemoglobin A1c, %	−0.039	0.36	−0.106	0.01	−0.069	0.10
Ghrelin, pg/mL	0.051	0.23	0.051	0.23	−0.015	0.72
Leptin, ng/mL	−0.177	<0.0001	−0.178	<0.0001	−0.070	0.10
Resistin, ng/mL	−0.033	0.43	−0.073	0.08	−0.051	0.23
Creatinine, mg/dL	−0.014	0.74	−0.054	0.20	−0.052	0.22
Estimated glomerular filtration rate, mL/min/1.73 m2	−0.195	<0.0001	−0.048	0.26	0.070	0.10
Lipid biomarkers
Total cholesterol, mg/dL	−0.130	0.002	−0.209	<0.0001	−0.196	<0.0001
Low density lipoprotein cholesterol, mg/dL	−0.151	0.0004	−0.228	<0.0001	−0.202	<0.0001
Oxidized low density lipoprotein cholesterol	−0.027	0.52	−0.087	0.04	−0.054	0.21
High density lipoprotein cholesterol, mg/dL	0.143	0.0007	0.132	0.002	0.070	0.10
Triglycerides, mg/dL	−0.110	0.009	−0.148	0.0005	−0.098	0.02
Free fatty acids mEq/L	0.031	0.46	−0.048	0.26	−0.022	0.61
Inflammatory biomarkers
High-sensitivity C-reactive protein, mg/L	0.016	0.70	−0.026	0.54	0.050	0.24
Interleukin (IL)-6, pg/mL	0.076	0.07	−0.009	0.83	0.047	0.27
Soluble intracellular adhesion molecule-1, ng/mL	0.006	0.89	−0.090	0.03	−0.061	0.15