Table 3.
Risk of incident diabetes according to baseline concentration of NT-proBNP.
| Adjusted Risk of Incident Type 2 Diabetes | ||||||
|---|---|---|---|---|---|---|
| Model | Quartile 1 | Quartile 2 | Quartile 3 | Quartile 4 | P-trend | Per 1 unit SD* |
| NT-proBNP range (ng/L) | <37.4 | 37.4 to < 64.2 | 64.2 to < 117.0 | ≥117.4 | ||
| Model 1 | 1.0 | 0.56 (0.40–0.78) | 0.61 (0.43–0.85) | 0.40 (0.27–0.60) | <0.001 | 0.68 (0.58–0.79) |
| P-value | 0.0006 | 0.004 | <0.0001 | <0.001 | ||
| Model 2 | 1.0 | 0.84 (0.56–1.26) | 0.93 (0.61–1.42) | 0.54 (0.33–0.89) | 0.047 | 0.79 (0.67–0.94) |
| P-value | 0.40 | 0.75 | 0.015 | 0.007 | ||
| Model 3 | 1.0 | 0.88 (0.58–1.34) | 0.97 (0.62–1.51) | 0.51 (0.30–0.86) | 0.041 | 0.78 (0.65–0.93) |
| P-value | 0.56 | 0.89 | 0.011 | 0.006 | ||
| Model 4 | 1.0 | 0.96 (0.63–1.47) | 0.99 (0.63–1.56) | 0.58 (0.35–0.97) | 0.10 | 0.80 (0.67–0.96) |
| P-value | 0.86 | 0.97 | 0.039 | 0.016 | ||
Model 1: Age and race adjusted
Model 2: Model 1 plus BMI (kg/m2) and BMI squared
Model 3: Model 2 plus eGFR, hormone therapy use, family history of diabetes, exercise at least once per week, alcohol use at least 1 drink per day.
Model 4: Model 3 plus insulin (μIU/mL)
Abbreviations: SD, standard deviation
*
Per 1 unit standard deviation (SD) of the natural logarithm-transformed NT-proBNP value.