Table 4.

Association of common variants in the NPPA-NPPB region with natural logarithm-transformed NT-proBNP concentrations. For each of the SNPs, the smallest P-value was seen when an additive (rather than dominant) mode of inheritance was assumed.

						Per-allele association with 1 SD change in natural log-transformed NT-proBNP concentrations*
SNP	Chr	Position	Minor/Major Allele	MAF†	Quality Score	Beta (standard error)	P-Value
rs198358‡	1	11826663	C/T	0.236	N/A	0.0829 (0.0680)	0.228
rs5068	1	11828561	G/A	0.059	0.998	−0.0035 (0.1255)	0.978
rs632793	1	11833264	G/A	0.409	0.962	0.2012 (0.0631)	0.0015
rs198389	1	11841858	G/A	0.427	0.987	0.1860 (0.0620)	0.0029

Abbreviations: SNP, single nucleotide polymorphism; Chr, chromosome; MAF, minor allele frequency; SD, standard deviation.

^*Adjusted for Age, BMI, and systolic blood pressure. The mean (SD) natural logarithm transformed NT-proBNP concentration in the reference subcohort is 4.254 (0.821).

^†Minor allele frequency in the participants of European descent with available genotyping information and NT-proBNP concentrations. rs198358 was directly genotyped; genotyping information for the remaining SNPs was imputed.

^‡This test of association used directly measured genotypes. The results did not differ when missing genotypes at rs198358 (n=1, or 0.22%) were replaced with the imputed estimated genotype dose.