TABLE 4.
Other MuLV Gr-1.4 integration sites
| Genea | Virus integration site localization | Databaseb | Tumorsc | Subtype of tumord | Chromosome
|
Gr-1.4 virus unique CIS (x) or sourcee | Family member identified in other studies | Unique database identifier | |
|---|---|---|---|---|---|---|---|---|---|
| Mouse | Human | ||||||||
| Protein-arginine deiminase type 1 (Pdi-1, PADI1) | 0.5 kb upstream of gene, intron 1 (upstream of and downstream of ATG) | C, E | 5/13 | II, III, IV | 4E1 | 1p36.1 | RTCGD | Pdi-2 (RTCGD) | NM_011059 |
| Myosin IC synaptic vesicle | Intron 1 (upstream of ATG) | C, E | 12/39 | II, III, IV | 9D | 15q22.2 | RTCGD | Myosin 1B, myosin IIIA (RTCGD) | XM_207764 |
| Glycoprotein 2A (Sv2A) | 27 kb upstream of gene | E | 1 | III | 3F2 | 1q23.1 | RTCGD | NM_022030 | |
| Swap70 | Intron 3 (downstream of ATG) | C, E | 1 | IV | 8C3 | 19p13.2 | RTCGD | NM_009302 | |
| PAFAH1B2 | 11 kb downstream of gene | E, N | 1 | III | 9B | 11q23.3 | RTCGD | NM_008775 | |
| Netrin 1 | Intron 1 (downstream of ATG) | C, E | 1 | ND | 11B3 | 17p11.2 | x | XM_193630 | |
| Multispanning membrane protein (TM9SF2) | 1 kb upstream of gene | C, E | 1 | III | 14E5 | 13q32.3 | RTCGD | NM_080556 | |
| Histone H3.3A (H3F3A) | Exon 1 (downstream of ATG) | C, N | 1 | IV | 1H4 | 1q41 | x | H1b, H1c, H2 (RTCGD) | Z85979 |
| Gene trap locus 13 (GTL1-13) | 17 kb upstream of gene | C, E | 2 | III | 2E1 | 11q12 | x | NM_021512 | |
| Tumor differentially expressed Tde1 | 15 kb upstream of gene | C, E | 1 | IV | 2H3 | 20q13.12 | RTCGD | NM_012032 | |
| O-Methyltransferase | 4.5-25 kb upstream of gene | E | 2 | III | 14B | 10q22.2 | x | AK007659 | |
| CHD2 | 17.3-18.8 kb upstream of gene | C, E | 11/13 | I, II, III, IV | 7D1 | 15q26.1 | x | NM_001271 | |
| Blm | 0.8-3 kb upstream of gene | C, E | 4/30 | II | 7D2 | 15q26.1 | x | NM_007550 | |
| VDUP1 | 1.6 kb upstream of gene to intron 1 (downstream of ATG), exon 8 (downstream of stop) to 3 kb downstream of gene | C, E, N | 14/14 | I, III, IV | 3F2 | 1q21 | x | AF282826 | |
| PrdxII | 2.4 kb upstream of gene to intron 1 (upstream of ATG) | C, E | 14/14 | I, II, III, IV | 8C3 | 19p13.2 | x | NM_011563 | |
| Lymphocyte antigen (Y-6M, LY-6A.2/LY-6E.1; TAP) | 6 kb downstream of gene | C, E | 8/39 | II, III, IV, V | 10C3 | 12q22 | x | Lymphocyte antigens 108, 74, and 6E (RTCGD) | NM_010738 |
| Periaxin | 57 kb upstream of gene | E | 5/13 | II, III, IV | 7A3 | 19q13.1 | x | AJ222968 | |
| RNase H1 subunit | 3 kb upstream of gene | C, E | 14/14 | I, II, III, IV | 8C3 | 19p13.2 | x | AK010292 | |
| Apoptosis inhibitory 5 (Api-5), fibroblast growth factor 2-interacting factor 2 | 6 kb downstream of gene, intron 1 (downstream of ATG) | C, E | 5/25 | I, III | 2E1 | 11p11.2 | x | NM_007466 | |
| Hematopoietic progenitor (CDCA4) | Intron 1 (upstream of ATG) | C, E | 2/13 | IV | 14E5 | 13q23.3 | x | AK010535 | |
| U1 snRNP binding protein | 1 kb upstream of gene | C, E | 2 | II, III | 5F | ? | x | AK018232 | |
| Unnamed | Intron 1 (downstream of ATG) | C, E | 3/13 | II, III | 15F2 | 12q12 | x | AK002729 | |
| Unnamed | 1.5 kb downstream of gene | C, E | 5/13 | II, III, IV | 7F4 | 16p13.11 | x | AK004043 | |
| Unnamed | 0.1-1.5 kb upstream of exon 1 | C, E | 9/12 | II, III, IV | 8C1 | 19p13.11 | x | AK013135 | |
| Unnamed | Intron 1 (downstream of ATG) | E | 5/25 | I, III | 2E1 | 11p11.2 | x | AK001752 | |
| Lim domain protein Ril | Intron 1 (downstream of ATG) | C, E | 2/13 | I, II | 11B1.3 | 5q31.1 | x | NM_019417 | |
| D6MM5e | Intron 4 (downstream of ATG) | C, E, N | 10/10 | I, II, III | 6D1 | 2p13 | x | AF084364 | |
| Psmb-1 | 1 kb upstream of gene | C, E | 1 | ND | 17A2 | 6q27 | x | Psmb-8 (RTCGD) | NM_011185 |
| Ubiquitin | 13 kb upstream of gene | C, E | 9/12 | II, III, IV | 8C1 | 19p13.11 | x | Many (RTCGD) | NM_019639 |
| Psme-1 | 0.34 kb upstream of gene | C, E | 1 | IV | 14C1 | 14q11.2 | x | Psmb-8 (RTCGD) | AB007136 |
| Ddx-21 | 2 kb downstream of gene | C, E | 1 | IV | 10B4 | 10q22.1 | x | Ddx-3, Ddx-6, Ddx-26 (RTCGD) | NM_019553 |
| Actin-like | 0.2 kb upstream of gene | C, E | 1 | III | 10C2 | 12q23.1 | x | β-Actin (RTCGD) | AK008409 |
| Alpha-1 catenin | 83 kb upstream of gene | C, E | 1 | III | 18B3 | 5q31.2 | NM_009818 | ||
| VDAC-2 | 7.5 kb downstream of gene | C | 1 | III | 14B | 10q22.2 | x | VDAC-1 (RTCGD) | NM_011695 |
| Proteoglycan, secretory granule (PRG1) | 1.1 kb upstream of gene | C, E | 1 | I | 10B4 | 10q22.1 | x | PRG4 (RTCGD) | NM_011157 |
| Potassium channel Kcnk5 | Intron 1 (downstream of ATG) | C, E | 1 | II | 14A3-B | 6p21.2 | RTCGD | NM_021542 | |
| FK506BP8 | 0.2-6.5 kb upstream of gene | C, E | 9/12 | II, III, IV | 8C1 | 19p13.11 | x | FK506BP3, FK506BP10 (RTCGD) | NM_010223 |
| MCT related | 10 kb upstream of gene | C, E | 1 | III | 11B4 | 17p13.2 | x | MCT4 (RTCGD) | AB041591 |
| RNA binding motif 5 | 2.2-3 kb upstream of gene | E, N | 3/11 | I, III | 9F2 | 3p21.31 | x | AJ309168 | |
| RNA binding motif 6 | 3-4.8 kb downstream of gene | E, N | 3/11 | I, III | 9F2 | 3p21.31 | x | NM_011251 | |