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. Author manuscript; available in PMC: 2014 Jun 4.
Published in final edited form as: Cell Metab. 2013 Jun 4;17(6):954–964. doi: 10.1016/j.cmet.2013.04.003

Figure 3. Hormetic mtROS Longevity Signaling Requires the Tel1p and Rad53p DNA-damage Response Kinases.

Figure 3

(A) Schematic of DNA-damage signaling in Saccharomyces cerevisiae.

(B) CLS of sml1Δ and sml1Δ/rad53Δ strains treated with 50 μM menadione (MD) or vehicle (nt) during exponential growth.

(C) ROS levels in sml1Δ and sml1Δ/rad53Δ strains treated with menadione (+) or vehicle (−) during exponential growth as in Figure 1D. Samples were collected at day one of CLS.

(D) CLS of wild-type (DBY2006) and tel1Δ strains as in (B). See also Figure S2.