Table 2.
Heart Rate, Mean Arterial Pressure, Arterial Oxygen Saturation, and Spirometry Parameters of the Three Groups at 397 m and 3658 m (The First Day)
| |
Acetazolamide |
Ginkgo biloba |
Placebo |
|||
|---|---|---|---|---|---|---|
| Variables | 397 m | 3658 m | 397 m | 3658 m | 397 m | 3658 m |
| HR | 76 (68, 84) | 85 (73, 90)* | 76 (72, 81) | 88 (79, 96)* | 72 (63, 81) | 79 (68, 91)* |
| MAP | 85 (76, 90) | 88 (83, 94) | 84 (77, 90) | 88 (83, 93) | 84 (80, 89) | 88 (84, 92) |
| SaO2% | 97.6 (97.2, 97.9) | 93.7 (92.4, 95.0)†‡ | 97.6 (97.2, 97.9) | 90.0 (88.3, 91.7)† | 97.5 (97.0, 98.0) | 91.2 (89.0, 93.5)† |
| LLS§ | 0 (0–1) | 1 (0–7) | 0 (0–1) | 5 (0–9) | 0 (0–2) | 3 (2–9) |
| FVC | 4.7 (4.4, 4.9) | 4.7 (4.3, 5.1) | 4.7 (4.5, 5.0) | 4.7 (4.3, 5.1) | 4.8 (4.5, 5.2) | 4.8 (4.4, 5.2) |
| FEV1% | 85.2 (79.5, 90.8) | 85.8 (79.6, 92.0) | 85.8 (80.6, 90.9) | 85.7 (80.9, 90.4) | 88.1 (84.5, 91.6) | 89.7 (86.5, 92.9) |
| PEF | 8.2 (7.1, 9.3) | 9.9 (9.2, 10.5)† | 8.6 (7.5, 9.6) | 10.0 (8.7, 11.2)† | 9.0 (8.1, 9.8) | 10.4 (9.1, 11.8)† |
FEV1%, forced expiratory volume in one second/forced vital capacity; FVC, forced vital capacity, liters; HR, heart rate, beats/minute; LLS, Lake Louise score; MAP, mean arterial pressure, mm Hg; PEF, peak expiratory flow, liters/minute. SaO2%, arterial oxygen saturation. Data are shown as mean and 95% CI.
*
p<0.05, †p<0.01: Paired Samples t Test, comparing the measurement at 3658 m with the measurement at 397 m; ‡p<0.05, one-way ANOVA with Bonferroni multi-comparison test, comparing acetazolamide or ginkgo biloba with the placebo group. §Data are shown as median and range.