Table 3.
Analysis of association with rheumatoid arthritis (RA) in four cohorts of non-imputed genotypes of C1q single nucleotide polymorphism (SNP) rs292001.
| Patients | Controls | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Cohort | Nationality | AA | AG | GG | n | AA | AG | GG | n | OR (95% CI) | P |
| Leiden | Dutch | 0·17 | 0·52 | 0·31 | 845 | 0·16 | 0·45 | 0·39 | 979 | 0·72 (0·75–0·88) | 0·0006 |
| NARAC I | USA | 0·17 | 0·46 | 0·37 | 868 | 0·13 | 0·46 | 0·41 | 1193 | 0·83 (0·69–1·00) | 0·043 |
| GCI | USA | 0·16 | 0·47 | 0·37 | 469 | 0·15 | 0·46 | 0·39 | 464 | 0·93 (0·70–1·20) | 0·548 |
| Crete | Greek | 0·11 | 0·51 | 0·38 | 269 | 0·14 | 0·46 | 0·41 | 369 | 0·89 (0·64–1·25) | 0·502 |
| Meta | 0·80 (0·72–0·89) | 0·0001 | |||||||||
Genotype counts of the non-imputed data for the cohorts from Leiden, North American Rheumatoid Arthritis Consortium (NARAC), Genomics Collaborative, Inc. (GCI) and Crete are depicted, including odds ratios (OR), confidence intervals (CI) and P-value. Also a meta-analysis was performed on these non-imputed data sets.