Table 2.

MMPs and vascular EC function in angiogenesis.

MMPs	Functions/effects	Substrates/signaling pathway	Outcomes	References
MMP-1	Proliferation↑	PAR-1/NF-κB→VEGFR2	Angiogenesis Vascular remodeling	[77, 78]
MMP-8	Proliferation/migration↑	Ang I→PECAM-1→β-catenin	Angiogenesis	[79]
MT1-MMP	Migration/invasion↑	ECM (collagen)	Vascular formation	[80–83]
MMP-9	Migration/invasion↑	ECM	Angiogenesis	[84]
MMP-2	Survival/apoptosis↑	Caspases and p38 MAPK	Angiogenesis Angioregression	[59, 85]
MMP-12	Proliferation/migration↑	uPAR	Systemic sclerosis	[86–88]
MMP-7	Proliferation/migration↑	Soluble VEGFR-1	Angiogenesis	[89, 90]